TISSUES

Tissue expression database

SH2D1A tissues

SH2D1A [ENSP00000360181]

SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 . However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 . Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

Synonyms:  SH2D1A,  SH2D1Ap,  hSH2D1A,  A0A2R8Y573,  O60880 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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