TISSUES

Tissue expression database

IER5 tissues

IER5 [ENSP00000356549]

Immediate early response gene 5 protein; Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1- dependent manner . Mediates negative transcriptional regulation of CDC25B expression . Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A . Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation . Associates with chromatin to the CDC25B promoter . ECO:0000269|PubMed:22132193, ECO:0000269|PubMed:25355627,; Belongs to the IER family.

Synonyms:  IER5,  IER5p,  hIER5,  Q5VY09,  Q5VY09p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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