TISSUES

Tissue expression database

IVNS1ABP tissues

IVNS1ABP [ENSP00000356468]

Influenza virus NS1A-binding protein; Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription . In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors . Inhibits pre-mRNA splicing (in vitro) .

Synonyms:  IVNS1ABP,  H0Y5Y2,  Q9Y6Y0,  X6R674,  H0Y5Y2p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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