TISSUES

Tissue expression database

WTAP tissues

WTAP [ENSP00000351141]

Pre-mRNA-splicing regulator WTAP; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Required for accumulation of METTL3 and METTL14 to nuclear speckle . Acts as a mRNA splicing regulator . Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability . Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes . ECO:0000269|PubMed:17095724, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:24981863,

Synonyms:  WTAP,  A0A087X1R4,  Q15007,  Q15007p,  hQ15007 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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