TISSUES

Tissue expression database

DNAJB12 tissues

DNAJB12 [ENSP00000345575]

DnaJ homolog subfamily B member 12; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum- associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers . While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 . When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear . ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912,

Synonyms:  DNAJB12,  DNAJB12p,  hDNAJB12,  J3KPS0,  Q9NXW2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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