ZGPAT tissues
ZGPAT [ENSP00000332013]
Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
Synonyms: ZGPAT, A0A0S2Z5X3, Q8N5A5, X6RGY1, Q8N5A5p ...