TISSUES

Tissue expression database

RNF40 tissues

RNF40 [ENSP00000325677]

E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes; Belongs to the BRE1 family.

Synonyms:  RNF40,  RNF40p,  hRNF40,  A0A087WTK2,  H3BP71 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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