TISSUES

Tissue expression database

MAGEF1 tissues

MAGEF1 [ENSP00000315064]

Melanoma-associated antigen F1; Enhances ubiquitin ligase activity of RING-type zinc finger- containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair .

Synonyms:  MAGEF1,  MAGEF1p,  hMAGEF1,  Q9HAY2,  Q9HAY2p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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