TRIB1 tissues
TRIB1 [ENSP00000312150]
Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase . The COP1- binding motif is masked by autoinhibitory interactions with the protein kinase domain . Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA . Binds selectively the recognition sequence of CEBPA . Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity . ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:26455797,; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Synonyms: TRIB1, TRIB1p, hTRIB1, E5RFH4, Q96RU8 ...