NDST2 tissues
NDST2 [ENSP00000310657]
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan . ECO:0000269|PubMed:12634318, ECO:0000269|PubMed:16343444,
Synonyms: NDST2, NDST2p, hNDST2, H7C032, P52849 ...