TISSUES

Tissue expression database

ARPC2 tissues

ARPC2 [ENSP00000295685]

Actin-related protein 2/3 complex subunit 2; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . Seems to contact the mother actin filament . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . ; Belongs to the ARPC2 family.

Synonyms:  ARPC2,  ARPC2p,  hARPC2,  C9JTV5,  G5E9J0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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