TISSUES

Tissue expression database

CYP39A1 tissues

CYP39A1 [ENSP00000275016]

24-hydroxycholesterol 7-alpha-hydroxylase; A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed:25201972, PubMed:10748047). Catalyzes 7-alpha hydroxylation of (24S)- hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) .

Synonyms:  CYP39A1,  CYP39A1p,  hCYP39A1,  A0A087WTD2,  Q9NYL5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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