CTDSP1 tissues
CTDSP1 [ENSP00000273062]
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Synonyms: CTDSP1, CTDSP1p, hCTDSP1, A0A024R461, H7C1Z7 ...