TISSUES

Tissue expression database

IL36RN tissues

IL36RN [ENSP00000259212]

Interleukin-36 receptor antagonist protein; Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti- inflammatory signaling pathway by recruiting SIGIRR.

Synonyms:  IL36RN,  IL36RNp,  hIL36RN,  A0A024R518,  C9JTH1 ...

Linkouts:  STRING  Pharos  UniProt

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