TISSUES

Tissue expression database

PLAAT4 tissues

PLAAT4 [ENSP00000255688]

Phospholipase A and acyltransferase 4; Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity . Shows O- acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which serves as precursor for N- acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Promotes keratinocyte differentiation via activation of TGM1 . ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22605381,

Synonyms:  PLAAT4,  PLAAT4p,  hPLAAT4,  A6NG31,  Q9UL19 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

0 1 2 3 4 5 Confidence