FBXL12 tissues
FBXL12 [ENSP00000247977]
F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
Synonyms: FBXL12, FBXL12p, hFBXL12, K7EIK3, K7EIR3 ...