TISSUES

Tissue expression database

INSIG2 tissues

INSIG2 [ENSP00000245787]

Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.

Synonyms:  INSIG2,  INSIG2p,  hINSIG2,  A0A024RAI2,  A0A0C4DGZ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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